研究設計

這項研究包括失代償期慢性乙肝280例，其中男性228例，肝硬化115例，使用拉米夫定100 mg/day **1-50個月，停止**后進行至少12個月的隨訪。隨訪期間對患者進行監測，前6個月監測1-3次，之后每3-6個月監測1次。采用Kaplan-Meier估計比較肝硬化和非肝硬化患者的非**事件（包括肝功能失代償（DE），肝細胞癌（HCC）和死亡）發生率。

研究結果

停止**后隨訪12-180個月（中位數：89.1），24.64％的患者發生非**事件，包括55例DE（16％），18例肝癌（6.4％）和3例死亡（1.1％）。肝硬化患者的DE，肝癌和死亡發生率仍然很低，但明顯高于非肝硬化患者。

結論

這項回顧性研究表明，大多數NA**成功的患者可以停止NA**，甚至肝硬化患者也是的，但停止**后必須嚴格進行隨訪和監測。

原文摘要

Background/Aims : Guidelines of major liver associations recommend that nucleot(s)ide analogue (NA) therapy should usually be continued indefinitely in chronic hepatitis B patients with decompensated cirrhosis. However, there is no eviden to support this recommendation. We therefore examined this issue using an earlier lamivduine treated cohort to study the outcomes of stopping NA therapy.

Methods : The study patients included 280 patients with decompensated chronic hepatitis B (228 males; 115 cirrhosis) who were treated with lamivudine 100mg/day for 1-50 months and were followed-up after ssation of therapy for at least 12 months. Their baseline features are listed in Table. After stopping therapy, they were monitored every 1-3 in the first 6 months and then every 3-6 months. The inciden of off-therapy events including hepatic decompensation (DE), hepatollular carcinoma (HCC) and mortality were compared between cirrhotic and non-cirrhotic patients using Kaplan-Meier estimates.

Results : Events occurred in 24.64 % of the patients during a follow-up period of 12-180 (median:89.1) months after stopping therapy, including 55 DE (16%), 18 HCC (6.4 %) and 3 mortalities (1.1 %). The inciden of DE, HCC and mortality remained low in cirrhotic patients though significantly higher than that of non-cirrhotic counterparts (Table).

Conclusion : The results of this retrospective study show that NA can be stopped safely in the majority of patients who were sucssfully rescued by NA therapy, even in cirrhotic patients. Proper off therapy monitoring is mandatory.